Mometasome Furoate Cream USP 0.1 :- http://oppsvitiligo.blogspot.com
Mometasone Furoate Cream USP 0.1:-
Mometasone Furoate Cream USP , 0.1% contains mometasone furoate , USP fordermatologic use. Mometasone furoate is a synthetic corticosteroid with anti-inflammatory activity.
Chemically , mometasone furoate is 9alpha ray,21-Dichloro-11beta ray , 17-dihydroxy-16alpha ray-methylpregna-1,4-diene-3,20-dione 17-(2-furoate), with the empirical formula C27H30cl2o6 , a molecular weight of 521.4 and the following structural formula :
Mometasome furoate is a white to off-white powder practically insoluble in water , slightly soluble in octanol , and moderately soluble in ethyl alcohal.Each gram of mometasone furoate cream USP , 0.1% contains 1 mg mometasone furoate , USP in a cream base of hexylene glycol , phosphoric acid , propylene glycol strearate , stearyl alcohol alcohol and ceteareth 20 , titanium dioxide , aluminum starch octenylsuccinate , beeswax ,white petralatum , and purified water .
CLINICAL PHARMACOLOGY :-
Like other topical corticosteroids , mometasone furoate has anti-inflammatory , anti-pruritic , and vasoconstrictive proporties. The mechanism of the anti-inflammatory activity of the topical steroids , in general , is unclear . However , corticosteroids are thought to act by the induction of phospholipase A2 inhibitory proteins , collectively called lipocortins . It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor arachidonic acid. Arachidonic acid is released from membrance phospholipids by phospholipase A2.
Dosage and Administration :-
Apply a thin film of mometasome furoate cream USP , 0.1 % to the affected skin areas once daily . Mometasome furoate cream USP , 0.1 % may be used in pediatric patients 2 years of age or older . Since safety and efficacy of mometasone furoate cream USP , 0.1% have not been adequately established in pediatric patients below 2 years of age , its use in this age group is not recommended . As with other corticosteroids , therapy should be discontinued when control is achieved . If no improvement is seen within 2 week , reassessment of diagnosis may be necessary . Safety and efficacy of mometasone furoate cream USP , 0.1% in pediatric patients for more than 3 week of use have not been established.
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