New Medicine for vitiligo. MUST READ :
In the lab , Experts focus on two aspects of Vitiligo :-Firstly , They study how abnormal , "stressed" melanocytes alert the immune system to their presence. Once stressed , melanocytes produce signals , that recruit T cells to the skin , which then find the melanocytes and kill them.
Secondly , They study how the T cells detect these signals , enter the skin , find the melanocytes , and kill them.
For the seek of vitiligo patients , experts use mouse as model , that had white spot on there body as shown in figure :-
Examining these mice from many angles , their disease looks very similar to human vitiligo . The benefit of this system is the powerful tools available to study diseases in mice. They are developing humanized mouse model of vitiligo , where they transfer human T cells , or both T cells and skin , from vitiligo patients to immunosuppressed mice that permit the growth of human tissues. The benefit of this system is the ability to study human T cells and skin and it has the potential to test new treatment on human tissues before attempting clinical trials.
They are conducting a clinical trial to investigate new drug as treatment for vitiligo :-
They were able to identify one of the critical pathways used by T cells to crawl into the skin and find melanocytes. The first signal in the pathway is IFN-g , a protein made by immune cells , which act as a powerful master switch to turn on immune responses. IFN-g then turns on CXCL10, which is required for the ability of T-cells to find melanocytes and kill them. Imagine , an ant that has found a new piece of food on the ground. The ant then lays a chemical trail that others follow to the food.CXCL10 acts acts like that chemical trail , promoting both proper localization of T cells to Find the melaocytes , and also increase their determination to kill them. There are existing drugs that have been developed by pharmaceutical companies that block the ability of CXCL10 to function in humans, and so they may be effective treatments in vitiligo as well.
They have also begun to identify the signals produced by stressed melaocytes that activate immune cells. We believe that studying the communication between stressed melanocytes and immune cells will tells us how vitiligo gets started in the first place, and how to better prevent its onset and spread.
Recently done clinical trial upon mice , stunts all , as shown in figure :-
Stay with us for latest news on this topics as i consult with some expert and take there reviews .
